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Since SA levels in the distal tissue are too low to inhibit SABP2, the transported MeSA is converted to active SA, which then induces and/or primes various systemic defense responses

Dias C, Moore KT, Murphy J, Ariyawansa J, Smith W, Mills RM, Weir MR

some use up to 1 g/day for more robust increases in NAD+ levels Suggested Brands: Tru Niagen (Niagen is a patented form of NR) and Thorne ResveraCel (includes NR plus additional antioxidants) NMN (Nicotinamide Mononucleotide) Typical Dose: 250500 mg/day (up to 1 g/day if well-tolerated) Suggested Brands: ProHealth and Alive by Nature (offers sublingual forms for potentially enhanced absorption) How to Choose the Best NAD Supplement As with any supplement, its important to look for one that has independent, third-party research supporting its formulation, efficacy and safety

153 RagoneseP.DamelioM.SalemiG.AridonP.GamminoM.EpifanioA.et al (2004)